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Title: | Quinpirole induces compulsive checking behavior in rats: A potential animal model of obsessive-compulsive disorder (OCD). |
Authors: | Szechtman H Sulis W Eilam D |
Department: | Psychiatry & Behavioural Neurosciences |
Keywords: | Animals;Clomipramine;Disease Models, Animal;Dopamine Agonists;Male;Obsessive-Compulsive Disorder;Orientation;Quinpirole;Rats;Rats, Long-Evans;Serotonin Uptake Inhibitors;Stereotyped Behavior |
Publication Date: | Dec-1998 |
Publisher: | American Psychological Association (APA) |
Abstract: | Rats treated chronically with the dopamine agonist quinpirole (0.5 mg/kg, twice weekly x 10) met 5 criteria for performance of compulsive checking. Specifically, in a large open-field with single small objects in 4 of 25 locales, quinpirole rats revisited two places/objects excessively often and rapidly, compared with other locations in the environment or saline controls. They performed a ritual-like set of behavioral acts at these two places/objects and stopped in relatively few locales before returning to the preferred places/objects. Finally, they shifted their behavior to a new location when the object was moved there. Clomipramine (10 mg/kg, daily) postponed but did not prevent the development of the quinpirole effect. Quinpirole-induced compulsive checking may be an exaggeration of normal checking of home site in rats. Results suggest an animal model of obsessive-compulsive disorder and a role for dopamine in this disorder. |
URI: | http://hdl.handle.net/11375/26795 |
metadata.dc.identifier.doi: | https://doi.org/10.1037/0735-7044.112.6.1475 |
ISSN: | 0735-7044 1939-0084 |
Appears in Collections: | Psychiatry & Behavioural Neurosciences Publications |
Files in This Item:
File | Description | Size | Format | |
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Szechtman1998_BN_QuinpiroleInduces_bneurosFinal.pdf | Accepted version | 684.26 kB | Adobe PDF | View/Open |
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