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http://hdl.handle.net/11375/26604
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DC Field | Value | Language |
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dc.contributor.author | Bognanni A | - |
dc.contributor.author | Schiaffino A | - |
dc.contributor.author | Pimpinelli F | - |
dc.contributor.author | Donzelli S | - |
dc.contributor.author | Celesti I | - |
dc.contributor.author | Strano S | - |
dc.contributor.author | Solari E | - |
dc.contributor.author | Schiaffino G | - |
dc.contributor.author | Solari G | - |
dc.contributor.author | Solari D | - |
dc.contributor.author | Delbue S | - |
dc.contributor.author | Rigoni M | - |
dc.contributor.author | Nollo G | - |
dc.contributor.author | Muti GE | - |
dc.contributor.author | Muti Schünemann GEU | - |
dc.contributor.author | Schünemann HJ | - |
dc.contributor.author | Blandino G | - |
dc.contributor.author | Morrone A | - |
dc.contributor.author | Muti P | - |
dc.date.accessioned | 2021-06-15T16:23:11Z | - |
dc.date.available | 2021-06-15T16:23:11Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 2001-0370 | - |
dc.identifier.issn | 2001-0370 | - |
dc.identifier.uri | http://hdl.handle.net/11375/26604 | - |
dc.description.abstract | Objectives: Despite an extensive risk of exposure to COVID-19, the residents of Giglio Island, Italy, did not develop any symptom of SARS-CoV-2. The present study aims to characterize the nature of exposure and to describe the local population dynamics underlying its apparent resistance to COVID-19. Methods: Descriptive study of an islander partially-segregated population cohort based on a seroprevalence screening conducted from Aprile 29 to May 3, 2020 and including SARS-CoV-2 seroprevalence and viral prevalence in samples of saliva assessed through RT-qPCR. Serologic testing was performed using a COVID-19 IgG/IgM rapid test while molecular analyses were carried out by Allplex 2019-nCoV Assay (Seegene). Results: A total of 634 residents out of 748 (84.8%) present at the time, and 89 non-residents underwent serological testing. 364 males and 359 females with a median age of 58.5 years. The serological screening identified one positive, asymptomatic subject. The Nucleic Acid Amplification Tests (NAAT) did not yield any positive result. Conclusion: Despite extensive exposure to SARS-CoV-2, possibly only one new asymptomatic infection occurred in this population, as documented by IgM positivity not confirmed by RT-qPCR. This may be due to unknown protective factors or chance. On the basis of this baseline study, using its population as a reference model, further investigations will be conducted to test the advanced hypotheses, focusing on the evaluation of a possible cross-reactivity to SARS-CoV-2 from exposure to endemic viruses. | - |
dc.publisher | Elsevier BV | - |
dc.rights.uri | 2 | - |
dc.subject | COVID-19 | - |
dc.subject | Giglio Island | - |
dc.subject | SARS-CoV-2 | - |
dc.title | The Conundrum of Giglio Island: Unraveling the dynamics of an apparent resistance to COVID-19 – A descriptive study | - |
dc.type | Article | - |
dc.date.updated | 2021-06-15T16:23:10Z | - |
dc.rights.license | Attribution - CC BY | - |
dc.identifier.doi | https://doi.org/10.1016/j.csbj.2021.02.008 | - |
Appears in Collections: | Faculty Publications (via McMaster Experts) |
Files in This Item:
File | Description | Size | Format | |
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The Conundrum of Giglio Island Unraveling the dynamics of an apparent resistance to COVID-19 - A descriptive study.pdf | Published version | 368.84 kB | Adobe PDF | View/Open |
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