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Please use this identifier to cite or link to this item: http://hdl.handle.net/11375/26538
Title: Cardiac Troponin Testing in Patients with COVID-19: A Strategy for Testing and Reporting Results
Authors: Kavsak PA
Hammarsten O
Worster A
Smith SW
Apple FS
Keywords: COVID-19;acute care;cardiac troponin;risk stratification;Biomarkers;COVID-19;Cardiovascular Diseases;Humans;Pandemics;SARS-CoV-2;Sensitivity and Specificity;Troponin
Publication Date: 8-Jan-2021
Publisher: Oxford University Press (OUP)
Abstract: <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged late in 2019 causing COVID-19 (coronavirus disease-2019) may adversely affect the cardiovascular system. Publications from Asia, Europe, and North America have identified cardiac troponin as an important prognostic indicator for patients hospitalized with COVID-19. We recognized from publications within the first 6 months of the pandemic that there has been much uncertainty on the reporting, interpretation, and pathophysiology of an increased cardiac troponin concentration in this setting.</jats:p> </jats:sec> <jats:sec> <jats:title>Content</jats:title> <jats:p>The purpose of this mini-review is: a) to review the pathophysiology of SARS-CoV-2 and the cardiovascular system, b) to overview the strengths and weaknesses of selected studies evaluating cardiac troponin in patients with COVID-19, and c) to recommend testing strategies in the acute period, in the convalescence period and in long-term care for patients who have become ill with COVID-19.</jats:p> </jats:sec> <jats:sec> <jats:title>Summary</jats:title> <jats:p>This review provides important educational information and identifies gaps in understanding the role of cardiac troponin and COVID-19. Future, properly designed studies will hopefully provide the much-needed evidence on the path forward in testing cardiac troponin in patients with COVID-19.</jats:p> </jats:sec>
URI: http://hdl.handle.net/11375/26538
metadata.dc.identifier.doi: https://doi.org/10.1093/clinchem/hvaa225
ISSN: 0009-9147
1530-8561
Appears in Collections:Faculty Publications (via McMaster Experts)

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