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DC Field | Value | Language |
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dc.contributor.author | McKechnie T | - |
dc.contributor.author | Bao T | - |
dc.contributor.author | Fabbro M | - |
dc.contributor.author | Ruo L | - |
dc.contributor.author | Serrano PE | - |
dc.date.accessioned | 2021-01-21T18:20:35Z | - |
dc.date.available | 2021-01-21T18:20:35Z | - |
dc.date.issued | 2020-11-06 | - |
dc.identifier.issn | 0003-1348 | - |
dc.identifier.issn | 1555-9823 | - |
dc.identifier.uri | http://hdl.handle.net/11375/26159 | - |
dc.description.abstract | <jats:sec><jats:title>Background</jats:title><jats:p> Liver resection is commonly performed among patients at risk of being frail. Frailty can be used to assess perioperative risk. Thus, we evaluated frailty as a predictor of postoperative complications following liver resection using a validated modified frailty index (mFI). </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> A retrospective cohort of consecutive patients undergoing liver resection (2011-2018) were stratified according to the mFI and classified as the following: high (≥.27) and low mFI (<.27). The effect of mFI on postoperative complications (Clavien-Dindo) was evaluated using multiple logistic regression, expressed as odds ratios (OR) and 95% CI. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> Of 409 patients, 58 (14%) had high mFI. There were no differences in type of liver resection (laparoscopic: 57% vs 55%, P = .766), number of segments resected (3 vs 4, P = .417), or operative time (257 vs 293 minutes, P = .097) between the high and low mFI groups, respectively. High mFI patients had a longer median length of hospital stay (9.5 vs 5 days, P < .001) and higher proportion of postoperative complications (79% vs 46%, P < .001), including minor complications (69% vs 42%, P < .001), major complications (50% vs 13%, P < .001), and 90-day postoperative mortality (12% vs 3.4%, P = .04). On multivariable analysis, longer operating time (OR 1.15, 95% CI, 1.03 to 1.27), higher number of segments resected (OR 1.43, 95% CI, 1.12 to 1.82), and high mFI (OR 6.74, 95% CI, 2.76 to 16.51) were independent predictors of major postoperative complications. </jats:p></jats:sec><jats:sec><jats:title>Discussion</jats:title><jats:p> mFI predicts postoperative outcomes following liver resection and can be used as a risk stratification tool for patients being considered for surgery. </jats:p></jats:sec> | - |
dc.publisher | SAGE Publications | - |
dc.subject | frailty | - |
dc.subject | liver resection | - |
dc.subject | morbidity | - |
dc.subject | mortality | - |
dc.subject | postoperative complications | - |
dc.title | Frailty as a Predictor of Postoperative Morbidity and Mortality Following Liver Resection | - |
dc.type | Article | - |
dc.date.updated | 2021-01-21T18:20:35Z | - |
dc.contributor.department | Surgery | - |
dc.identifier.doi | 10.1177/0003134820949511 | - |
Appears in Collections: | Surgery Publications |
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