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http://hdl.handle.net/11375/25427
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DC Field | Value | Language |
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dc.contributor.advisor | Rathbone, Michel | - |
dc.contributor.author | Atayde, Adrienne Lloyd | - |
dc.date.accessioned | 2020-05-05T19:00:11Z | - |
dc.date.available | 2020-05-05T19:00:11Z | - |
dc.date.issued | 2020 | - |
dc.identifier.uri | http://hdl.handle.net/11375/25427 | - |
dc.description.abstract | Background: Up to 20% of concussion patients do not recover and develop a host of persisting cognitive, physical, behavioural, and/or emotional symptoms – collectively known as post-concussion syndrome (PCS) – lasting for many months to years. It is unclear why these patients have protracted recovery. Identifying factors that can predict patients at most risk can provide earlier targets for prevention and treatment. However, the wide-ranging list of predictors of PCS is creating confusion in the body of literature, and despite countless reviews attempting to clarify this growing list, there remains a great deal of uncertainty. Objective: To systematically map the reviews on PCS predictors to determine the nature of the reviews and understand why this body of literature still lacks firm, conclusive evidence. We aimed to identify sources of clinical and methodological diversity that hinder meta-analytic syntheses, and in turn, limit the conclusions drawn and translated to clinical practice. Methods: The Joanna Briggs Institute Reviewer’s Manual and the PRISMA-ScR was used to develop our study design. Six databases were searched, including reference lists. Studies needed to sufficiently focus on predicting PCS and report challenges relevant to quantitative synthesis. Results: 281 eligible studies were found. Eleven studies were included in the final qualitative analysis. Qualitative synthesis revealed definitions and diagnostic barriers, as well as methodological barriers, contribute to clinical and methodological diversity in studies. Conclusions: Despite extensive research on PCS predictors, researchers are faced with definitions and diagnostic barriers and methodological barriers that influence the clinical and methodological diversity across studies. These sources of barriers and diversity impede the conduct of more meta-analytic approaches, and in turn, limits review studies from reaching more conclusive evidence that can reliably inform clinical practice. Understanding of the nature of literature reviews can help inform researchers of the sources of diversity and barriers to improve research contributions to evidence-based medicine. | en_US |
dc.language.iso | en | en_US |
dc.title | THE CHALLENGES ASSOCIATED WITH PREDICTING POST-CONCUSSION SYMPTOMS: A SCOPING REVIEW OF LITERATURE | en_US |
dc.type | Thesis | en_US |
dc.contributor.department | Medical Sciences | en_US |
dc.description.degreetype | Thesis | en_US |
dc.description.degree | Master of Science in Medical Sciences (MSMS) | en_US |
dc.description.layabstract | Background: Despite countless reviews attempting to clarify the extensive list of predictors for post-concussion syndrome, there remains a great deal of uncertainty. Objective: To determine the characteristics of the existing review studies on predictors for developing post-concussion syndrome and identify obstacles in quantitatively combining studies and translating the evidence into clinical practice. Methods: Six databases were systematically searched to find relevant reviews examining predictors of post-concussion syndrome. Eligible studies went through multistage screening to determine whether they meet the eligibility criteria. Results: 281 studies were eligible for screening, of which, 11 studies were included. Obstacles regarding definitions and diagnostic criteria and study methods were contributing to increased diversity across the studies. Conclusions: The obstacles identified in this study all contribute to the challenges in combining individual studies into a quantitative synthesis that, in turn, limit the clear conclusions that can be drawn and the translation of research evidence to clinical use. | en_US |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Description | Size | Format | |
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ATAYDE_ADRIENNELLOYD_2020APRIL_MSc.pdf | 399.85 kB | Adobe PDF | View/Open |
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