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|Title:||The influence of short-term aerobic training on muscle hypertrophy and satellite cell content following resistance training in healthy young men and women.|
|Abstract:||Resistance exercise training is the most effective and accepted strategy for increasing skeletal muscle mass and strength. There is tremendous individual variability in the adaptive response to exercise and the source(s) contributing to this variability are largely unknown. Recent evidence in the literature supports the notion that capillaries may be a potential target for improving outcomes to chronic resistance exercise. Aerobic exercise training is a proven stimulus for eliciting angiogenesis and increasing capillary content. Therefore, we hypothesize that completing a period of aerobic training prior to resistance training will result in a greater increase in fibre cross sectional area (CSA) compared to resistance training alone. Fourteen participants (8M, 6F) completed 6 weeks of unilateral single leg aerobic training prior to undergoing 10 weeks of bilateral lower body resistance exercise training. Performance and anthropometric measures were completed at baseline, post aerobic training and post resistance training. Skeletal muscle biopsies were obtained from the vastus lateralis and immunofluorescent staining of muscle cross sections was completed to determine fibre CSA and satellite cell content. Following unilateral aerobic training, single leg VO2 work peak (Watts) (p<0.001), and oxygen consumption (O2 mL min-1) (p=.0033) was significantly higher in the aerobically trained limb (EX) versus the control (CTL) limb. Capillary to perimeter fibre exchange index (CFPE) (p<0.05), a measure of microvascular perfusion, was significantly higher in the EX versus CTL limb following unilateral aerobic training. Resistance training resulted in increases in 1-repetition maximum of both squat (p<0.0001) and leg press (p<0.0001). A main effect of time was observed for limb fat free mass (p<0.0001) as determined via DEXA. Type-II fibre CSA of the EX limb was greater (p<0.05) versus CTL limb following resistance exercise training. Type-II fibre associated satellite cell content of the CTL limb was elevated (p<0.01) following resistance training. Results suggest that a period of unilateral aerobic training elevates the aerobic capacity and relative microvascular perfusion of the trained leg significantly in comparison to the non-aerobically conditioned limb. Subsequent resistance training, bilateral leg strength increased post resistance training while type II CSA increased in the aerobically pre-conditioned limb following resistance training. Collectively, these results suggest that a period of aerobic preconditioning may augment the muscle’s ability to respond to a hypertrophic stimulus.|
|Appears in Collections:||Open Access Dissertations and Theses|
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|Thomas_Aaron_CQ_November 2019_M.Sc.pdf||Thomas_Aaron_CQ_November 2019_M.Sc.||9.25 MB||Adobe PDF||View/Open|
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