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Please use this identifier to cite or link to this item: http://hdl.handle.net/11375/24679
Title: CORTICAL EXCITABILITY AND INHIBITION IN POST-CONCUSSION SYNDROME
Authors: Locke, Mitchell
Advisor: Nelson, Aimee
Department: Kinesiology
Keywords: Concussion;Transcranial magnetic stimulation;mTBI;motor cortex
Publication Date: 2019
Abstract: Post-concussion syndrome (PCS) is a poorly understood sequela of mild traumatic brain injury (mTBI), more commonly referred to as concussion. While PCS is known to affect a subset of individuals following injury, it remains unclear how and why specific individuals incur chronic symptoms. Concussions disrupt normal neurophysiologic function within the brain, however the neurophysiologic underpinnings of PCS are unclear. Using transcranial magnetic stimulation (TMS), it is possible to non-invasively investigate neurotransmission in clinical populations such as those with PCS by stimulating the primary motor cortex (M1) and recording motor outputs in a contralateral hand muscle. A study was conducted using TMS to measure corticospinal excitability, intracortical facilitation and inhibition, and transcallosal inhibition in M1 of a group with PCS and a non-injured, healthy control group. Greater corticospinal excitability, and specific reductions in intracortical and transcallosal inhibition were observed in the PCS group, providing evidence of impaired neurotransmitter receptor activity. Importantly, these findings differed from previous observations in recovered concussion groups using similar stimulation techniques. Furthermore, it was observed that these neurophysiological differences may relate specifically to the presence of depression symptoms rather than general concussion symptoms. The physiologic and clinical implications of the findings of this thesis are discussed, and novel research avenues warranting investigation are identified.
URI: http://hdl.handle.net/11375/24679
Appears in Collections:Open Access Dissertations and Theses

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