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DC Field | Value | Language |
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dc.contributor.advisor | McNeill, Fiona | - |
dc.contributor.author | Stuive, Rachel Monique | - |
dc.date.accessioned | 2019-01-28T18:10:30Z | - |
dc.date.available | 2019-01-28T18:10:30Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | http://hdl.handle.net/11375/23826 | - |
dc.description.abstract | Non-invasive techniques to measure bone fluorine levels in vivo are few and not well studied. These techniques would prove useful for longitudinal studies of fluorine accumulation and treatment optimization for patients with poor bone health. Two measurement techniques were analyzed and improvements to each technique attempted with bone samples and bone-mimicking phantoms. The first method analyzed was neutron activation analysis (NAA), a technique previously studied in our laboratory. A previous detector setup consisting of nine sodium iodide detectors was re-tested and a new detector setup consisting of two high-purity germanium detectors was also tested. The detection limit of the sodium iodide setup was found to be higher than previously reported by a factor of 4, and the new high-purity germanium detector setup was found to result in a higher detection limit by a factor of 5 compared to the sodium iodide setup. The second method analyzed was nuclear magnetic resonance (NMR). Magic angle spinning was performed on a human bone sample, and a novel probe was constructed for future in vivo measurements. MAS NMR measurement of the human bone sample showed it to have an appropriate chemical shift and shape consistent with previous research on substances similar to bone. The constructed probe successfully resonated at the appropriate frequency, however there were potential contamination problems which prevented a measurable fluorine signal from being obtained. Both the NAA and NMR techniques may be optimized further, though with the results obtained, NAA remains the more sensitive technique for measuring bone fluorine in vivo. | en_US |
dc.language.iso | en | en_US |
dc.subject | Fluorine | en_US |
dc.subject | Bone | en_US |
dc.subject | Neutron Activation Analysis | en_US |
dc.subject | Nuclear Magnetic Resonance | en_US |
dc.title | Analysis and modifications of two in vivo methods for determining fluorine content in bone | en_US |
dc.type | Thesis | en_US |
dc.contributor.department | Radiation Sciences (Medical Physics/Radiation Biology) | en_US |
dc.description.degreetype | Thesis | en_US |
dc.description.degree | Master of Science (MSc) | en_US |
dc.description.layabstract | Fluorine is an element which accumulates in bones and teeth. High levels of fluorine have been shown to be unhealthy, causing both dental and skeletal fluorosis. Low levels of fluorine have been shown to reduce dental cavities, however, their effect on bone health is not well understood. Currently, fluorine can be measured in bone samples from either biopsies or cadavers. Having a non-invasive way to measure fluorine concentrations in living humans without the need for surgery would be invaluable. These measurements could be used to optimize treatment for osteoporosis patients or to determine if emergency measures are necessary in cases of high accidental doses to members of the public. Additionally, long-term studies examining fluorine metabolism and bone health could be performed on population groups of interest. For these reasons, two different non-invasive methods for determining fluorine content in bone were analyzed and enhancements to each measurement technique attempted. | en_US |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Description | Size | Format | |
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Stuive_Rachel_M_2018September_M.Sc.Thesis.pdf | 11.08 MB | Adobe PDF | View/Open |
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