Please use this identifier to cite or link to this item:
http://hdl.handle.net/11375/22261
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Ask, Kjetil | - |
dc.contributor.author | Tandon, Karun | - |
dc.date.accessioned | 2017-10-18T12:28:06Z | - |
dc.date.available | 2017-10-18T12:28:06Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | http://hdl.handle.net/11375/22261 | - |
dc.description.abstract | Fibroproliferative disorders are the leading cause of morbidity and mortality worldwide, with one specific group of fibroproliferative disorders being interstitial lung diseases (ILD). Idiopathic pulmonary fibrosis is the most common ILD; however its pathogenesis is not entirely understood. What is known is that there is repetitive cellular injury preceding the fibrotic remodeling in the lungs that contributes to the irreversible deposition of extracellular matrix (ECM) proteins. Myofibroblasts that accumulate at the site of injury are thought to be the key drivers of ECM deposition and are often associated in the disease. Although it is poorly understood how these immune cells differentiate in the lung, one hypothesis suggests the role of alternatively activated profibrotic macrophages in this process. The data presented in this thesis suggest that there are a presence of UPR and macrophage proteins in the lungs of IPF patients and the UPR may be necessary in the polarization of alternatively activated macrophages. | en_US |
dc.language.iso | en | en_US |
dc.subject | Idiopathic Pulmonary Fibrosis | en_US |
dc.subject | M2 macrophages | en_US |
dc.subject | Alternatively Activated Macrophages | en_US |
dc.subject | Interstitial Lung Disease | en_US |
dc.subject | Nintedanib | en_US |
dc.subject | Fibroblasts | en_US |
dc.subject | Myofibroblasts | en_US |
dc.subject | Unfolded Protein Response | en_US |
dc.subject | IRE1 | en_US |
dc.subject | XBP1 | en_US |
dc.subject | ER stress | en_US |
dc.title | The Role of the Unfolded Protein Response and Alternatively Activated Macrophages in Pulmonary Fibrosis. | en_US |
dc.title.alternative | THE UNFOLDED PROTEIN RESPONSE, ALTERNATIVELY ACTIVATED MACROPHAGES, AND IPF | en_US |
dc.type | Thesis | en_US |
dc.contributor.department | Medical Sciences | en_US |
dc.description.degreetype | Thesis | en_US |
dc.description.degree | Master of Science (MSc) | en_US |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Tandon_Karun_finalsubmission2017_July_MSc.pdf | 14.67 MB | Adobe PDF | View/Open |
Items in MacSphere are protected by copyright, with all rights reserved, unless otherwise indicated.