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http://hdl.handle.net/11375/21977| Title: | Ophthalmic Biomaterials |
| Authors: | Muirhead, Ben |
| Advisor: | Sheardown, Heather |
| Department: | Biomedical Engineering |
| Keywords: | Biomaterials;Ophthalmology;cell delivery;cell scaffold;drug delivery;mucoadhesive |
| Publication Date: | Nov-2017 |
| Abstract: | This thesis will explore, both generally and very specifically, the role of biomaterials in drug delivery and tissue engineering applications. A novel therapeutic conjugate to treat dry eye disease using hyaluronic acid and sulfadiazine was created and tested using a benzalkonium chloride induced dry eye model. Thermoresponsive hydrogels based around poly(n-isopropylacrylamide) were synthesized to create a potential in situ gelling cell scaffold for cell delivery to the subretinal space. Finally, a mucoadhesive micelle was developed as a platform delivery system to increase bioavailability of drug in anterior segment therapeutics. |
| URI: | http://hdl.handle.net/11375/21977 |
| Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Muirhead_Ben_B_201705_PhD_Biomedical Engineering.pdf | 3.95 MB | Adobe PDF | View/Open |
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