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http://hdl.handle.net/11375/20745| Title: | Exploring the effects of chronic vitamin C deficiency in a mouse model of Her2-positive breast cancer |
| Authors: | Kelly, Rachel |
| Advisor: | Schellhorn, Herb |
| Department: | Biology |
| Publication Date: | 2017 |
| Abstract: | Vitamin C (VC) is an antioxidant that humans must include in their diet to prevent scurvy. High intake of VC may reduce the incidence of some types of cancer, and high-dose intravenous VC is an alternative cancer therapy. In this study, we used a genetically modified mouse to model the effects of chronic VC deficiency in breast cancer. Mice were fed either a low-dose or normal-dose VC diet, and were monitored for cancer development. We found that there was no difference in tumour characteristics between the mice that received low-dose versus normal VC supplementation. The results of this study suggest that chronic VC deficiency may not have an effect in this specific type of breast cancer. |
| URI: | http://hdl.handle.net/11375/20745 |
| Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Kelly_Rachel_K_2016October_MSc.pdf | 1.19 MB | Adobe PDF | View/Open |
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