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Please use this identifier to cite or link to this item: http://hdl.handle.net/11375/20584
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dc.contributor.advisorZiegler, F. D.-
dc.contributor.authorVigers, Gary Alexander-
dc.date.accessioned2016-09-29T16:43:42Z-
dc.date.available2016-09-29T16:43:42Z-
dc.date.issued1970-09-
dc.identifier.urihttp://hdl.handle.net/11375/20584-
dc.description.abstract<p> The present investigation was concerned with mitochondrial energy transfer reactions and their relationship to mitochondrial structural integrity. Experiments with azide demonstrated a close relationship between oxidative phosphorylation and large amplitude mitochondrial volume changes. Azide inhibited energy transfer and energy-linked mitochondrial swelling by competing with adenine nucleotide for a site on the terminal phosphorylating enzyme. As a permeant anion azide exerted secondary effects on mitochondrial structure and function.</p> <p> Experiments with mitochondria treated with phlorizin and phloretin emphasized the importance of Mg++ as a controlling factor in maintaining the integrity of mitochondrial energy transfer processes. The results indicated that these compounds interfered directly with oxidative phosphorylation, and that mitochondrial swelling was either a consequence of impaired energy transfer, or a separate phenomenon.</p>en_US
dc.language.isoen_USen_US
dc.subjectenergy transfer processes, Mammalian, mitochondria, oxidative phosphorylationen_US
dc.titleStudies of Energy Transfer Processes in Mammalian Mitochondriaen_US
dc.typeThesisen_US
dc.contributor.departmentBiochemistryen_US
dc.description.degreetypeThesisen_US
dc.description.degreeDoctor of Philosophy (PhD)en_US
Appears in Collections:Digitized Open Access Dissertations and Theses

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