Please use this identifier to cite or link to this item:
http://hdl.handle.net/11375/20584
Title: | Studies of Energy Transfer Processes in Mammalian Mitochondria |
Authors: | Vigers, Gary Alexander |
Advisor: | Ziegler, F. D. |
Department: | Biochemistry |
Keywords: | energy transfer processes, Mammalian, mitochondria, oxidative phosphorylation |
Publication Date: | Sep-1970 |
Abstract: | <p> The present investigation was concerned with mitochondrial energy transfer reactions and their relationship to mitochondrial structural integrity. Experiments with azide demonstrated a close relationship between oxidative phosphorylation and large amplitude mitochondrial volume changes. Azide inhibited energy transfer and energy-linked mitochondrial swelling by competing with adenine nucleotide for a site on the terminal phosphorylating enzyme. As a permeant anion azide exerted secondary effects on mitochondrial structure and function.</p> <p> Experiments with mitochondria treated with phlorizin and phloretin emphasized the importance of Mg++ as a controlling factor in maintaining the integrity of mitochondrial energy transfer processes. The results indicated that these compounds interfered directly with oxidative phosphorylation, and that mitochondrial swelling was either a consequence of impaired energy transfer, or a separate phenomenon.</p> |
URI: | http://hdl.handle.net/11375/20584 |
Appears in Collections: | Digitized Open Access Dissertations and Theses |
Files in This Item:
File | Description | Size | Format | |
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Vigers_Gary_A._1970Sept_Ph.D..pdf | 3.21 MB | Adobe PDF | View/Open |
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