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Title: | Total Synthesis of Methyl O-Methyl-11-Desoxycarnosate |
Authors: | Oommen, Puthenpurackal Kurian |
Advisor: | Bell, R. A. |
Department: | Chemistry |
Keywords: | synthesis, methyl, desoxycarnosate, acid, hydrogenation |
Publication Date: | Sep-1968 |
Abstract: | <p> Synthetic methods for the preparation of 2,7-dimethoxy-1-naphthoic acid are presented. The selective reduction of this acid with sodium in liquid ammonia to give 1,4-dihydronaphthoic acid is described.</p> <p> The selective Birch reduction of 2,7-dimethoxynaphthalene to 1,4-dihydro-2,7-dimethoxynaphthalene has been accomplished. 2,7-Dimethoxy-3- isopropylnaphthalene was converted to 3-keto-12-methoxy-10-carbomethoxy-13-isopropylperhydrophenanthra-4,8,11,13-tetraene via, 1,2,3,4-tertrahydro-7-methoxy-6-isopropyl-1-carbomethoxynaphthalen-2-one. The transformation of 3-keto-12-methoxy-10-carbomethoxy-13-isopropylperhydrophenanthra-4,8,11,13- tetraene to methyl O-methyl-11-desoxycarnosate via methylation, thioketalisation, desulphurisation and hydrogenation is also described.</p> |
URI: | http://hdl.handle.net/11375/19761 |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Description | Size | Format | |
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Oommen_Puthenpurackal_K._1968Sept_Ph.D..pdf | 3.09 MB | Adobe PDF | View/Open |
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