Please use this identifier to cite or link to this item:
http://hdl.handle.net/11375/18152
Title: | A COMPARISON OF HIGHER VERSUS LOWER DIETARY PROTEIN INTAKE ON GLOMERULAR FILTRATION RATE IN HEALTHY ADULTS: A SYSTEMATIC REVIEW AND META-ANALYSIS |
Other Titles: | AN ANALYSIS OF HIGHER PROTEIN DIETS ON RENAL FUNCTION |
Authors: | SITHAMPARAPILLAI, ARJUN |
Advisor: | PHILLIPS, STUART, M. |
Department: | Global Health |
Keywords: | Chronic kidney disease, glomerular filtration rate, estimated glomerular filtration rate, creatinine clearance, dietary reference intake, diet, high protein diet, increased protein intake, randomized controlled trials, crossover trials, World Health Organization |
Publication Date: | Nov-2015 |
Abstract: | Background: Higher protein diets, especially from animal sources, have seen a rise in popularity due to potential metabolic. This may have consequences for kidney function particularly in rising middle class populations who are allocating more income towards meat. The objective of this systematic review and meta-analysis was to evaluate the effects of higher versus lower protein intake on glomerular filtration rate (GFR) in adult populations without renal impairment. Methods: Search strategies were developed and electronic databases searched: MEDLINE and EMBASE. Data were extracted up until June 3, 2015. The main outcome measure was GFR and a random effect model (Cochrane’s Review Manager Version 5.3) was used to pool mean differences in GFR values. Results: Database searches yielded 25 trials from 1914 articles that were eligible for analysis based on inclusion/exclusion criteria. 12 studies were randomized controlled trials and 11 studies were crossover trials. As a result of data presented, 2 crossover studies were treated as 4 trials to result in 25 total trials. A total of 810 subjects from 25 trials were included in this systematic review and meta-analyses. The age of participants was 24-62 years and their BMI was 21-36 kg/m2. Higher protein compared to lower protein-containing diets were associated with increased GFR values [mean difference (MD): 8.33 ml/min (95% CI 4.87 to 11.79), P < 0.00001] but this was less pronounced when assessing change from baseline GFR values [MD: 4.71 ml/min (95% CI 0.06 to 9.36), P = 0.05]. Moreover, significant heterogeneity was present and funnel plot asymmetry indicated potential publication bias in both meta-analyses. Conclusion: Higher protein diets were associated with increased GFR, however, these results were inconclusive due to significant heterogeneity and overestimation by random effect analyses. There is still no clear evidence that high protein diets negatively impact renal function in healthy populations. |
URI: | http://hdl.handle.net/11375/18152 |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
FINAL GRADUATE THESIS.pdf | Entire Thesis (Systematic Review and Meta-Analysis) | 1.01 MB | Adobe PDF | View/Open |
Items in MacSphere are protected by copyright, with all rights reserved, unless otherwise indicated.