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Title: | Biosynthesis of Vitamin B₆ |
Authors: | Hill, Robert Edward |
Advisor: | Spenser, I. D. |
Department: | Biochemistry |
Keywords: | biochemistry;biosynthesis;vitamin B₆;Escherichia coli B., WG2 |
Publication Date: | May-1970 |
Abstract: | The biosynthesis of vitamin B₆ was studied by administering radioactive putative precursors to a mutant of Escherichia coli B., WG2. A new method for the isolation and purification of the vitamin congener, pyridoxol, is described. Partial degradation of the radioactive pyridoxol revealed non-random incorporation of a number of precursors into pyridoxol. On the basis of these results a biosynthetic scheme was constructed which envisages that pyridoxol is derived from three glycerol units. One of these is incorporated via pyruvic acid as a two carbon fragment at the oxidation level of acetaldehyde. The other two are incorporated intact, possibly by way of triose phosphate (Fig. 33). |
URI: | http://hdl.handle.net/11375/17958 |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Description | Size | Format | |
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Hill_Robert_E_1970May_PhD.pdf | 32.38 MB | Adobe PDF | View/Open |
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