The Effect of N-Methyl-N'-Nitro-N-Nitrosoguanidine on Herpes Simplex Virus Replication and Gene Expression

Please use this identifier to cite or link to this item: http://hdl.handle.net/11375/17776

Full metadata record

DC Field	Value	Language
dc.contributor.advisor	Rawls, W. E.	-
dc.contributor.author	Arshoff, Larry Usher	-
dc.date.accessioned	2015-07-22T14:45:13Z	-
dc.date.available	2015-07-22T14:45:13Z	-
dc.date.issued	1978-12	-
dc.identifier.uri	http://hdl.handle.net/11375/17776	-
dc.description.abstract	Experiments were carried out to determine if pretreatment of cells with N-Methyl-N'-Nitro-N-Nitrosoguanidine (a potent alkylating agent known to induce DNA repair) would affect Herpes Simplex Virus Replication. The data demonstrated a 1.5 fold increase in virus yield, a 2 fold increase in HSV specific TK activity and no change in HSV specific DNA polymerase activity in MNNG treated cultures. The effects of MNNG treatment on virus replication and enzyme expression are discussed.	en_US
dc.language.iso	en	en_US
dc.subject	biology	en_US
dc.subject	N-Methyl-N'-Nitro-N-Nitrosoguanidine, MNNG	en_US
dc.subject	DNA repair	en_US
dc.subject	Herpes simplex virus	en_US
dc.subject	replication	en_US
dc.subject	gene expression	en_US
dc.subject	enzyme expression	en_US
dc.title	The Effect of N-Methyl-N'-Nitro-N-Nitrosoguanidine on Herpes Simplex Virus Replication and Gene Expression	en_US
dc.contributor.department	Biology	en_US
dc.description.degreetype	Thesis	en_US
dc.description.degree	Master of Science (MSc)	en_US
Appears in Collections:	Open Access Dissertations and Theses

Files in This Item:

File	Description	Size	Format
Arshoff_Larry_U_1978Dec_MSc.pdf Open Access		22.54 MB	Adobe PDF	View/Open