Please use this identifier to cite or link to this item:
http://hdl.handle.net/11375/15293
Title: | Surface Characterization and Comparison of Contact vs. Non-Contact Printed Sol-Gel Derived Material Microarrays |
Authors: | Helka, Blake-Joseph |
Advisor: | Brennan, John D. Capretta, Alfredo |
Department: | Chemical Biology |
Keywords: | microarrays;sol-gel;x-ray photoelectron spectroscopy;infrared spectroscopy;printing;Analytical Chemistry;Materials Chemistry;Analytical Chemistry |
Publication Date: | Oct-2013 |
Abstract: | <p>Fabrication of microarrays using sol-gel immobilization has been utilized as an approach to develop high density biosensors. Microarray fabrication using various printing techniques including pin-printing and piezoelectric ink jet printing methods has been demonstrated. However, only limited characterization to understand the encapsulated biomolecule-material interface has been reported. Herein, Chemical characterization using X-ray photoelectron spectroscopy (XPS) and infrared spectroscopy (IR) on pin-printed microarrays of sol-gel derived acetylcholinesterase (AChE) microarrays is reported. Furthermore, the <em>in situ</em> fabrication of microarrays following the sol-gel process using piezoelectric ink jet printing methods was explored. Through techniques measuring solution viscosity, surface tension and particle size, important aspects of bio-ink formulation for piezoelectric ink jet printing were identified. Combined, a greater understanding towards the fabrication and characterization of sol-gel derived microarrays was achieved through this exploratory research.</p> |
URI: | http://hdl.handle.net/11375/15293 |
Identifier: | opendissertations/8321 9451 4629927 |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Size | Format | |
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fulltext.pdf | 2.2 MB | Adobe PDF | View/Open |
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