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http://hdl.handle.net/11375/13959
Title: | CATECHOLAMINE-REGULATED PROTEIN 40 IN PARKINSON’S DISEASE |
Authors: | Lubarda, Jovana |
Advisor: | Gabriele, Joseph Mishra, Ram Doering, Laurie |
Department: | Neuroscience |
Keywords: | Catecholamine-regulated protein 40;Parkinson’s disease;movement disorder;protein cloning;oxidative stress;Diagnosis;Medical Biochemistry;Medical Molecular Biology;Nervous System Diseases;Therapeutics;Diagnosis |
Publication Date: | Apr-2014 |
Abstract: | <p>Parkinson’s disease (PD) is a complex neurodegenerative movement disorder involving protein misfolding, mitochondrial dysfunction, and oxidative stress. The current dissertation, motivated by a lack of valid biomarkers and sustainable therapies, examined the potential application of a novel target for therapeutics and diagnostics of PD — the multifunctional, heat-shock like protein Catecholamine-Regulated Protein 40 (CRP40). The goal of this program of research was to elucidate further the implications of CRP40 in PD using a variety of molecular biology, bioinformatics, and clinical approaches through integrative collaborations with academia, government, and industry partners to translate scientific findings into real world solutions. Chapters 2 and 3 explored the potential therapeutic use and structure-function relationships of CRP40 through elucidating the smallest functional piece of this protein that was six times smaller, and validating a negative control for these experiments (Heat-Shock Protein 47). These initiatives could eventually lead to a small drug that could cross the blood-brain barrier and be targeted to the specific brain regions affected in PD. Chapter 4 examined the potential mechanisms of CRP40, and suggested that this protein may protect neurons from oxidative stress, maintain energy levels, and mitochondrial homeostasis, with important future implications for a variety of disorders. Finally, Chapter 5 presented compelling evidence for the potential use of CRP40 as a valid biomarker for early detection of PD and monitoring of disease progression. Overall, findings suggest that CRP40 may be a critical target for future breakthroughs in the diagnosis and treatment of PD.</p> |
URI: | http://hdl.handle.net/11375/13959 |
Identifier: | opendissertations/8791 9858 5060668 |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Size | Format | |
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fulltext.pdf | 25.74 MB | Adobe PDF | View/Open |
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