Please use this identifier to cite or link to this item:
http://hdl.handle.net/11375/13625
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | MacDonald, Maureen | en_US |
dc.contributor.author | Cotie, Lisa | en_US |
dc.date.accessioned | 2014-06-18T17:04:39Z | - |
dc.date.available | 2014-06-18T17:04:39Z | - |
dc.date.created | 2013-10-24 | en_US |
dc.date.issued | 2014-04 | en_US |
dc.identifier.other | opendissertations/8460 | en_US |
dc.identifier.other | 9536 | en_US |
dc.identifier.other | 4763273 | en_US |
dc.identifier.uri | http://hdl.handle.net/11375/13625 | - |
dc.description.abstract | <p>A comprehensive understanding of the mechanisms regulating vascular structure and function may assist in designing effective strategies to decrease cardiovascular disease risk. The current studies were designed to investigate a) relationships between collagen markers and arterial stiffness and markers of vasoconstriction and inflammation and endothelial function in humans with a wide range of vascular health, including overweight women, elderly healthy men, individuals with coronary artery disease, individuals with spinal cord injury and young healthy men and b) changes in arterial structure and function and circulating serum markers of type I collagen synthesis and degradation, vasoconstriction and inflammation in overweight pre-menopausal women before and after a 16- week diet and exercise intervention. Resting brachial artery flow mediated dilation (FMD), upper limb and/or central pulse wave velocity (PWV<sub>c-r</sub> and PWV<sub>c-f</sub>) and carotid artery distensibility were assessed at baseline in all groups and, in the overweight population, after the 16-week intervention. Pro-collagen type I C-peptide (PIP), C-telopeptide of type I collagen (CTX), markers of collagen synthesis and degradation respectively, endothelin-1 (ET-1) a vasoconstrictor and interleukin-6 (IL-6) an inflammatory marker were measured. In the spectrum of vascular health, a negative relationship exists between collagen markers and central PWV (CTX–PWV<sub>c-f</sub>: r = -0.41, p = 0.001 and PIP – PWV<sub>c-f</sub>: r = -0.32, p = 0.01) and a positive relationship between markers and carotid distensibility (CTX: r = 0.59, pc-r increased over time in the overweight population (FMD pre: 4.1 ± 0.5 % vs. post: 6.9 ± 0.7 %, pc-r pre: 8.1 ± 0.3 m/s vs. post: 8.9 ± 0.3 m/s, p</p> | en_US |
dc.subject | collagen | en_US |
dc.subject | arterial stiffness | en_US |
dc.subject | endothelial dysfunction | en_US |
dc.subject | aerobic exercise | en_US |
dc.subject | resistance exercise | en_US |
dc.subject | vasoconstriction | en_US |
dc.subject | inflammation | en_US |
dc.subject | Cardiovascular System | en_US |
dc.subject | Cardiovascular System | en_US |
dc.title | Mechanisms Associated with the Regulation of Vascular Structure and Function in Humans | en_US |
dc.type | dissertation | en_US |
dc.contributor.department | Kinesiology | en_US |
dc.description.degree | Doctor of Philosophy (PhD) | en_US |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Size | Format | |
---|---|---|---|
fulltext.pdf | 1.91 MB | Adobe PDF | View/Open |
Items in MacSphere are protected by copyright, with all rights reserved, unless otherwise indicated.