Skip navigation
  • Home
  • Browse
    • Communities
      & Collections
    • Browse Items by:
    • Publication Date
    • Author
    • Title
    • Subject
    • Department
  • Sign on to:
    • My MacSphere
    • Receive email
      updates
    • Edit Profile


McMaster University Home Page
  1. MacSphere
  2. Open Access Dissertations and Theses Community
  3. Open Access Dissertations and Theses
Please use this identifier to cite or link to this item: http://hdl.handle.net/11375/13265
Title: AN EVALUATION OF MEASUREMENT OF ADHERENCE AND PATIENT RECRUITMENT METHODS IN PATIENT ADHERENCE TO MEDICATION RESEARCH
Authors: Jeffery, Rebecca A.
Advisor: Haynes, Brian R.
Lauren Griffith, Anne Holbrook
Department: Health Research Methodology
Keywords: Adherence;Measurement;Quality;Methodology;Patient Recruitment;Systematic Review;Clinical Epidemiology;Clinical Epidemiology
Publication Date: Oct-2013
Abstract: <p><strong>Objective: </strong>To provide an overview of the state of trial methodology concerning measurement of patient adherence and patient recruitment, and explore how the quality of these methods impact the adherence results found in trials.</p> <p><strong>Data sources: </strong>Major bibliographic sources, reference lists, and clinicaltrials.gov were searched for relevant trials up to January 2013.</p> <p><strong>Study selection: </strong>Approximately 150 trials were included in the full systematic review, from which 50 trials were selected to represent several methods of measuring adherence.</p> <p><strong>Results: </strong>There were a variety of different measures of adherence with qualities ranging from valid and unobtrusive, to unreliable and subjective. The median overall quality of adherence measures was 5 (IQR 3, maximum score 9, higher is better). The overall correlation of the quality of the measures of adherence and the coefficient of variation (CV) or proportion adherence suggested that adherence measures rated as higher quality were associated with a higher CV but not associated with a lower proportion adherence. The median overall quality of patient recruitment methods was 2 (IQR 1, maximum score 6, higher is better). The correlation of the power of a trial and the quality of the patient recruitment methods, was slightly positively correlated for both binary and continuous data.</p> <p><strong>Conclusions: </strong>The quality of methods employed in adherence trials varies considerably and affects at least some findings of these trials. The importance of these differences in quality merits further study, but it is clear that better standards of adherence measurement are needed to support adherence research.</p>
URI: http://hdl.handle.net/11375/13265
Identifier: opendissertations/8083
9045
4361311
Appears in Collections:Open Access Dissertations and Theses

Files in This Item:
File SizeFormat 
fulltext.pdf
Open Access
1.45 MBAdobe PDFView/Open
Show full item record Statistics


Items in MacSphere are protected by copyright, with all rights reserved, unless otherwise indicated.

Sherman Centre for Digital Scholarship     McMaster University Libraries
©2022 McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L8 | 905-525-9140 | Contact Us | Terms of Use & Privacy Policy | Feedback

Report Accessibility Issue