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http://hdl.handle.net/11375/12799
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DC Field | Value | Language |
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dc.contributor.advisor | Papaioannou, Alexandra | en_US |
dc.contributor.author | Pritchard, Janet M. | en_US |
dc.date.accessioned | 2014-06-18T17:00:47Z | - |
dc.date.available | 2014-06-18T17:00:47Z | - |
dc.date.created | 2012-12-31 | en_US |
dc.date.issued | 2013-04 | en_US |
dc.identifier.other | opendissertations/7655 | en_US |
dc.identifier.other | 8720 | en_US |
dc.identifier.other | 3558733 | en_US |
dc.identifier.uri | http://hdl.handle.net/11375/12799 | - |
dc.description.abstract | <p>The risk of fracture is higher in adults with type 2 diabetes compared to controls without type 2 diabetes, despite normal or higher than normal bone mineral density (BMD). In addition to BMD, bone strength depends on other factors such as structural and material <em>bone qualities</em>, which are not accounted for in BMD measurements. The objective was to determine whether structural and material <em>bone qualities</em> are different in adults with type 2 diabetes compared to controls without type 2 diabetes. First, a cross-sectional study was undertaken using MRI to investigate distal radius trabecular bone microarchitecture, a structural <em>bone quality.</em> In women with type 2 diabetes, trabecular bone holes were larger compared to controls, which is important because greater trabecular bone hole size is related to reduced bone strength. Next, a two year prospective study was conducted with the participants involved in the cross-sectional study to determine whether changes in trabecular bone microarchitecture are different in women with type 2 diabetes compared to controls. There was a greater increase in the number of trabecular bone holes in women with type 2 diabetes compared to controls, which provides early evidence of trabecularization of cortical bone in women with type 2 diabetes. In the third study, quantitative backscattered electron imaging (qBEI) was used to derive bone mineralization density distribution (BMDD) outcomes for bone samples from adults with and without type 2 diabetes to compare material <em>bone quality. </em>There was evidence of elevated bone calcium concentration and reduced mineralization heterogeneity in bone samples from adults with type 2 diabetes compared to controls, which may contribute to bone brittleness. In summary, differences in structural and material <em>bone qualities </em>identified in this body of work provide explanations for elevated fracture risk in adults with type 2 diabetes.</p> | en_US |
dc.subject | osteoporosis | en_US |
dc.subject | type 2 diabetes | en_US |
dc.subject | bone | en_US |
dc.subject | mineralization | en_US |
dc.subject | trabecular bone microarchitecture | en_US |
dc.subject | magnetic resonance imaging | en_US |
dc.subject | quantitative backscattered electron imaging | en_US |
dc.subject | bone quality | en_US |
dc.subject | fracture | en_US |
dc.subject | Endocrine System Diseases | en_US |
dc.subject | Geriatrics | en_US |
dc.subject | Musculoskeletal Diseases | en_US |
dc.subject | Nutritional and Metabolic Diseases | en_US |
dc.subject | Endocrine System Diseases | en_US |
dc.title | The Assessment of Structural and Material Bone Qualities in Adults with Type 2 Diabetes | en_US |
dc.type | thesis | en_US |
dc.contributor.department | Medical Sciences | en_US |
dc.description.degree | Doctor of Science (PhD) | en_US |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Size | Format | |
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fulltext.pdf | 3.28 MB | Adobe PDF | View/Open |
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