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Please use this identifier to cite or link to this item: http://hdl.handle.net/11375/12381
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dc.contributor.advisorMagarvey, Nathanen_US
dc.contributor.advisorMichael G. Surette, Paul H. M. Harrisonen_US
dc.contributor.authorLukenda, Nikolaen_US
dc.date.accessioned2014-06-18T16:59:23Z-
dc.date.available2014-06-18T16:59:23Z-
dc.date.created2012-08-24en_US
dc.date.issued2012-10en_US
dc.identifier.otheropendissertations/7274en_US
dc.identifier.other8329en_US
dc.identifier.other3258516en_US
dc.identifier.urihttp://hdl.handle.net/11375/12381-
dc.description.abstract<p>Nonribosomal peptides, polyketides, and fatty acids comprise a distinct subset of microbial secondary metabolites produced by similar biosynthetic methods and exhibit broad structural diversity with a high propensity for biological activity. Dedicated studies of these specific microbial small molecules have identified numerous potent actions towards human cells with many clinical translations. Interestingly, most therapeutically used nonribosomal peptides and polyketides were discovered from soil bacteria, meanwhile, bacteria that have co-evolved within a human context, the human microbiota, have barely been explored for secondary metabolites. The central goal of this thesis is to explore the secondary metabolome of human microbiota for nonribosomal peptides and polyketides, which are hypothesized to possess biological activities significant within the human host context. Candidate organisms were chosen for their established connections to human health and evidence suggestive of secondary metabolite production. Specifically, questions about gene to molecule prediction capability, metabolite production, structural diversity, and biological activity were explored from studies of the dental caries linked Streptococcus mutans UA159, from the probiotic Lactobacillus plantarum WCFS1, and the Crohn’s disease associated Faecalibacterium prausnitzii.</p>en_US
dc.subjecthuman microbiomeen_US
dc.subjectnonribosomal peptideen_US
dc.subjectNRPSen_US
dc.subjectpolyketideen_US
dc.subjectPKSen_US
dc.subjectprobioticen_US
dc.subjectgenome miningen_US
dc.subjectnatrual producten_US
dc.subjectNatural Products Chemistry and Pharmacognosyen_US
dc.subjectNatural Products Chemistry and Pharmacognosyen_US
dc.titleExploring the Role of Nonribosomal Peptides in the Human Microbiome Through the Oral Commensal Streptococcus mutans, the Probiotic Lactobacillus plantarum, and Crohn’s Disease Associated Faecalibacterium prausnitziien_US
dc.typethesisen_US
dc.contributor.departmentChemical Biologyen_US
dc.description.degreeMaster of Science (MSc)en_US
Appears in Collections:Open Access Dissertations and Theses

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