Skip navigation
  • Home
  • Browse
    • Communities
      & Collections
    • Browse Items by:
    • Publication Date
    • Author
    • Title
    • Subject
    • Department
  • Sign on to:
    • My MacSphere
    • Receive email
      updates
    • Edit Profile


McMaster University Home Page
  1. MacSphere
  2. Open Access Dissertations and Theses Community
  3. Open Access Dissertations and Theses
Please use this identifier to cite or link to this item: http://hdl.handle.net/11375/12380
Full metadata record
DC FieldValueLanguage
dc.contributor.advisordeCatanzaro, Denysen_US
dc.contributor.authorRajabi, Nazaninen_US
dc.date.accessioned2014-06-18T16:59:23Z-
dc.date.available2014-06-18T16:59:23Z-
dc.date.created2012-08-24en_US
dc.date.issued2012-10en_US
dc.identifier.otheropendissertations/7273en_US
dc.identifier.other8327en_US
dc.identifier.other3256330en_US
dc.identifier.urihttp://hdl.handle.net/11375/12380-
dc.description.abstract<p>Adhesion of the blastocyst to the uterine wall is a highly sensitive phenomenon referred to as implantation. Novel-males are capable of disrupting the success of this process (the Bruce effect). A leading hypothesis invokes the transfer of estradiol from the male to the female via urine. This estradiol has direct effect on the uterus which may include morphology and molecular dynamics. Estradiol has been related to closure of the uterus around the blastocyst during implantation, which may assist in bringing the blastocyst close to the uterine wall for strong adhesion. E-cadherin, a cellular adhesion molecule, is found on both blastocyst and uterine surfaces and has been suggested to be involved in their interaction during implantation. Estradiol has been observed to reduce e-cadherin expression in hormonally sensitive tissues like the mammary glands, ovaries and uteri. Here, male-induced disruption of implantation was examined across days 2-8 of gestation. Luminal area was quantified in isolated and male-exposed females as a measure of extent of luminal closure. This area was larger in male-exposed animals. E-cadherin was found to have reduced expression on luminal epithelial cells. I suggest that the reduction in e-cadherin may lead to weaker attachment of the blastocyst to the uterine wall as well as reduced adhesion between opposing uterine walls leading to the “opening” of the uterus observed in male exposed animals. Together, these data may in part explain the blastocyst implantation failure observed in male-exposed animals during the Bruce effect.</p>en_US
dc.subjectBruce Effecten_US
dc.subjectE-Cadherinen_US
dc.subjectImplantation Failureen_US
dc.subjectEstrogenen_US
dc.subjectLuminal Areaen_US
dc.subjectCellular and Molecular Physiologyen_US
dc.subjectEndocrinologyen_US
dc.subjectCellular and Molecular Physiologyen_US
dc.titleNovel-male induced pregnancy failure in mice: effects on implantation, luminal area and e-cadherinen_US
dc.typethesisen_US
dc.contributor.departmentNeuroscienceen_US
dc.description.degreeMaster of Science (MSc)en_US
Appears in Collections:Open Access Dissertations and Theses

Files in This Item:
File SizeFormat 
fulltext.pdf
Open Access
470.46 kBAdobe PDFView/Open
Show simple item record Statistics


Items in MacSphere are protected by copyright, with all rights reserved, unless otherwise indicated.

Sherman Centre for Digital Scholarship     McMaster University Libraries
©2022 McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L8 | 905-525-9140 | Contact Us | Terms of Use & Privacy Policy | Feedback

Report Accessibility Issue