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http://hdl.handle.net/11375/12055
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DC Field | Value | Language |
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dc.contributor.advisor | Mossman, Karen L. | en_US |
dc.contributor.advisor | Lichty, Brian D. | en_US |
dc.contributor.advisor | Ashkar, Ali | en_US |
dc.contributor.author | Chew, Tracy | en_US |
dc.date.accessioned | 2014-06-18T16:58:06Z | - |
dc.date.available | 2014-06-18T16:58:06Z | - |
dc.date.created | 2012-05-02 | en_US |
dc.date.issued | 2012-10 | en_US |
dc.identifier.other | opendissertations/6973 | en_US |
dc.identifier.other | 7983 | en_US |
dc.identifier.other | 2817276 | en_US |
dc.identifier.uri | http://hdl.handle.net/11375/12055 | - |
dc.description.abstract | <p>The transcription factor interferon (IFN) regulatory factor 3 (IRF-3) plays a central role in the innate immune response to viral stimulation. IRF-3 participates in both the type I IFN-dependent and -independent signalling pathways that result in the induction of an antiviral state. The work presented in this thesis characterizes the central role of IRF-3 in the IFN-independent response to virus particle entry. In addition, novel splice variants of human IRF-3 are identified and characterized, implying a role for splice-mediated regulation of IRF-3-mediated antiviral signalling. Finally, a role for reactive oxygen species in the activation of IRF-3 following virus particle entry is described, with virus particle entry inducing danger associated molecular patterns associated with IRF-3 activation and IFN-independent antiviral gene expression. Taken together, this thesis characterizes the role of IRF-3 in the innate antiviral signalling pathways activated following viral stimulation, and highlight the importance of danger-associated molecular patterns as important mediators of antiviral signalling.</p> | en_US |
dc.subject | innate immunity | en_US |
dc.subject | virology | en_US |
dc.subject | signalling | en_US |
dc.subject | cell biology | en_US |
dc.subject | molecular biology | en_US |
dc.subject | cytokines | en_US |
dc.subject | Medical Cell Biology | en_US |
dc.subject | Medical Cell Biology | en_US |
dc.title | THE ROLE OF INTERFERON REGULATORY FACTOR 3 IN THE INNATE ANTIVIRAL RESPONSE | en_US |
dc.type | thesis | en_US |
dc.contributor.department | Medical Sciences (Molecular Virology and Immunology Program) | en_US |
dc.description.degree | Doctor of Philosophy (PhD) | en_US |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Size | Format | |
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fulltext.pdf | 10.45 MB | Adobe PDF | View/Open |
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