Skip navigation
  • Home
  • Browse
    • Communities
      & Collections
    • Browse Items by:
    • Publication Date
    • Author
    • Title
    • Subject
    • Department
  • Sign on to:
    • My MacSphere
    • Receive email
      updates
    • Edit Profile


McMaster University Home Page
  1. MacSphere
  2. Open Access Dissertations and Theses Community
  3. Open Access Dissertations and Theses
Please use this identifier to cite or link to this item: http://hdl.handle.net/11375/12055
Full metadata record
DC FieldValueLanguage
dc.contributor.advisorMossman, Karen L.en_US
dc.contributor.advisorLichty, Brian D.en_US
dc.contributor.advisorAshkar, Alien_US
dc.contributor.authorChew, Tracyen_US
dc.date.accessioned2014-06-18T16:58:06Z-
dc.date.available2014-06-18T16:58:06Z-
dc.date.created2012-05-02en_US
dc.date.issued2012-10en_US
dc.identifier.otheropendissertations/6973en_US
dc.identifier.other7983en_US
dc.identifier.other2817276en_US
dc.identifier.urihttp://hdl.handle.net/11375/12055-
dc.description.abstract<p>The transcription factor interferon (IFN) regulatory factor 3 (IRF-3) plays a central role in the innate immune response to viral stimulation. IRF-3 participates in both the type I IFN-dependent and -independent signalling pathways that result in the induction of an antiviral state. The work presented in this thesis characterizes the central role of IRF-3 in the IFN-independent response to virus particle entry. In addition, novel splice variants of human IRF-3 are identified and characterized, implying a role for splice-mediated regulation of IRF-3-mediated antiviral signalling. Finally, a role for reactive oxygen species in the activation of IRF-3 following virus particle entry is described, with virus particle entry inducing danger associated molecular patterns associated with IRF-3 activation and IFN-independent antiviral gene expression. Taken together, this thesis characterizes the role of IRF-3 in the innate antiviral signalling pathways activated following viral stimulation, and highlight the importance of danger-associated molecular patterns as important mediators of antiviral signalling.</p>en_US
dc.subjectinnate immunityen_US
dc.subjectvirologyen_US
dc.subjectsignallingen_US
dc.subjectcell biologyen_US
dc.subjectmolecular biologyen_US
dc.subjectcytokinesen_US
dc.subjectMedical Cell Biologyen_US
dc.subjectMedical Cell Biologyen_US
dc.titleTHE ROLE OF INTERFERON REGULATORY FACTOR 3 IN THE INNATE ANTIVIRAL RESPONSEen_US
dc.typethesisen_US
dc.contributor.departmentMedical Sciences (Molecular Virology and Immunology Program)en_US
dc.description.degreeDoctor of Philosophy (PhD)en_US
Appears in Collections:Open Access Dissertations and Theses

Files in This Item:
File SizeFormat 
fulltext.pdf
Open Access
10.45 MBAdobe PDFView/Open
Show simple item record Statistics


Items in MacSphere are protected by copyright, with all rights reserved, unless otherwise indicated.

Sherman Centre for Digital Scholarship     McMaster University Libraries
©2022 McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L8 | 905-525-9140 | Contact Us | Terms of Use & Privacy Policy | Feedback

Report Accessibility Issue