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Please use this identifier to cite or link to this item: http://hdl.handle.net/11375/11509
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dc.contributor.advisorWohl, Gregoryen_US
dc.contributor.authorDruchok, Cheryl D.en_US
dc.date.accessioned2014-06-18T16:54:51Z-
dc.date.available2014-06-18T16:54:51Z-
dc.date.created2011-10-29en_US
dc.date.issued2012-04en_US
dc.identifier.otheropendissertations/6474en_US
dc.identifier.other7485en_US
dc.identifier.other2319982en_US
dc.identifier.urihttp://hdl.handle.net/11375/11509-
dc.description.abstract<p>A high-fat diet can adversely affect bone mechanical properties, but it is unknown how these changes affect bone adaptation. Bone adaptation occurs in response to strain-related mechanisms, and strain in the bone is affected by the size and mechanical properties of the bone.The purpose of this study was to compare the strain during loading in femurs from rats fed a high-fat (HF) or normal control (NC) diet. At 3 weeks of age, male and female Wistar rats were randomly assigned to receive a NC (NC–17% fat; N=8 per gender) or HF diet (HF–41% fat; N=8 per gender) until termination (39 weeks of age). Right femurs were loaded <em>ex vivo</em> in 3-point bending to physiologic levels and mechanical strain was measured. The mechanical properties of the left femurs were determined by 3-point bend tests to failure. The dietary effects were limited in both genders. Femoral cross-sectional area properties (bone area, moment of inertia), determined from µCT scans, were significantly greater in HF femurs vs. NC for males and females. Elastic modulus was calculated from strain and deformation data and no dietary effects were seen in either gender. At the applied loads, despite significantly larger cross-sectional area properties in the HF femurs, there was no significant difference in strain between HF and NC femurs for either gender. It appears that adaptive modeling occurs during growth in the HF bones to target a predetermined level of strain to preserve bone structural integrity.</p>en_US
dc.subjectboneen_US
dc.subjectbiomechanicsen_US
dc.subjectanimal modelsen_US
dc.subjectmechanical loadingen_US
dc.subjecthigh-fat dieten_US
dc.subjectBiomechanical Engineeringen_US
dc.subjectBiomechanical Engineeringen_US
dc.titleThe Effect of a High-Fat Diet on Bone Strain in Adult Rat Femursen_US
dc.typethesisen_US
dc.contributor.departmentBiomedical Engineeringen_US
dc.description.degreeMaster of Applied Science (MASc)en_US
Appears in Collections:Open Access Dissertations and Theses

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