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http://hdl.handle.net/11375/11353
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DC Field | Value | Language |
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dc.contributor.advisor | Atkinson, S.A. | en_US |
dc.contributor.author | Ng, Melody | en_US |
dc.date.accessioned | 2014-06-18T16:54:23Z | - |
dc.date.available | 2014-06-18T16:54:23Z | - |
dc.date.created | 2011-09-28 | en_US |
dc.date.issued | 2011-10 | en_US |
dc.identifier.other | opendissertations/6326 | en_US |
dc.identifier.other | 7378 | en_US |
dc.identifier.other | 2262799 | en_US |
dc.identifier.uri | http://hdl.handle.net/11375/11353 | - |
dc.description.abstract | <p>Emerging evidence indicates that in utero exposure to vitamin D metabolites may influence fetal and neonatal bone development. Bone accretion in prenatal and early postnatal life may impact peak bone mass achieved in early adolescence; and peak bone mass is a well-established predictor of osteoporosis risk in later life. <strong>Hypothesis</strong>: We hypothesized that offspring of mothers with higher serum vitamin D status during pregnancy will have higher whole body BMC z-score and bone size at 3 years of age, after adjustment for confounders. <strong>Methods</strong>: In a prospective, longitudinal study, 372 mothers with singleton birth were recruited during pregnancy, and maternal blood samples were obtained during the third trimester. Child bone outcome measures at 3 years of age included: whole body BMC, femoral and humeral lengths by DXA. We controlled for other relevant factors such as maternal nutrition, pre-pregnancy BMI, physical activity during pregnancy, maternal BMD, as well as the child’s nutrition at 6 months and 3 years, and the child’s physical activity. <strong>Results & Discussion</strong>: Maternal vitamin D status during pregnancy did not predict whole body BMC z-score of the child at 3 years of age. Over 92% of Canadian women in our sample were vitamin D sufficient with mean intakes of 435 IU/day from food and supplements and mean serum 25OHD of 111.2 nM. Further, data indicate a potential negative effect on offspring bone size at maternal serum 25OHD concentrations that exceed the upper limit suggested by the most recent DRI report (>125 nM), at which adverse health effects may occur. Our findings may differ from previous studies in the United Kingdom, India and Finland that found a positive relationship between maternal vitamin D status and child bone outcomes due to the high frequency of our mothers that had optimal vitamin D status. In addition, we adjusted for most of the key covariates that were not adjusted for in previous studies, which may contribute to the different findings compared to previous investigations.</p> | en_US |
dc.subject | vitamin D | en_US |
dc.subject | bone | en_US |
dc.subject | pregnancy | en_US |
dc.subject | developmental origins of health and disease | en_US |
dc.subject | nutrition | en_US |
dc.subject | maternal determinants of offspring health | en_US |
dc.subject | Medicine and Health Sciences | en_US |
dc.subject | Medicine and Health Sciences | en_US |
dc.title | MATERNAL VITAMIN D STATUS DURING PREGNANCY AS A PREDICTOR OF OFFSPRING BONE MASS AT THREE YEARS OF AGE | en_US |
dc.type | thesis | en_US |
dc.contributor.department | Medical Sciences | en_US |
dc.description.degree | Master of Science (MSc) | en_US |
Appears in Collections: | Open Access Dissertations and Theses |
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fulltext.pdf | 1.63 MB | Adobe PDF | View/Open |
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