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http://hdl.handle.net/11375/11245
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DC Field | Value | Language |
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dc.contributor.advisor | Wan, Yonghong | en_US |
dc.contributor.advisor | Brian Lichty, Jonathan Bramson | en_US |
dc.contributor.advisor | Brian Lichty, Jonathan Bramson | en_US |
dc.contributor.author | Zhang, Liang | en_US |
dc.date.accessioned | 2014-06-18T16:54:02Z | - |
dc.date.available | 2014-06-18T16:54:02Z | - |
dc.date.created | 2011-09-22 | en_US |
dc.date.issued | 2011-10 | en_US |
dc.identifier.other | opendissertations/6227 | en_US |
dc.identifier.other | 7249 | en_US |
dc.identifier.other | 2251771 | en_US |
dc.identifier.uri | http://hdl.handle.net/11375/11245 | - |
dc.description.abstract | <p>Cancer vaccine therapy aims at harnessing effective antigen specific immune responses to treat tumor. In particular, CD8+ T cells have the unique capacity to recognize and destroy tumor cell throughout the body. One potential approach to elicit high numbers of effector CD8+ T cells to control tumor growth is through repeated vaccination, a strategy called prime-boost vaccination. However, booster immunization is relatively inefficient during primary immune response because pre-activated effector T cells tend to impair robust antigen presentation. This phenomenon has been interpreted as a negative feedback mechanism where recently activated CD8+ T cells clear the antigen-bearing dendritic cells (DCs) and prevent memory T cells from the access of the boosting antigen. Interestingly, however, using in vitro activated B cell as a viral vector delivery system, we can boost T cell responses with the minimum viral input at a very short interval between immunizations. This B cell carrier is capable of delivering different viral vectors expressing different antigens, displaying a potential for broad application. The mechanisms behind B cell carrier-mediated efficient secondary responses are three fold: 1. Without the engagement of MHC molecules and antigen presentation, B cell carrying viral vector can bypass the killing by pre-existing effector T cells 2. B cells can delivery viruses to B cell follicles, a place separated from effector T cells, and mediate memory T cell expansion. 3. B cells can deliver antigen to both spleen and lymph node and induce antigen specific T cell expansion in multiple lymphoid organs. Our studies provide a novel boosting platform to accelerate CTL responses that has important clinical implications.</p> | en_US |
dc.subject | cancer immunotherapy | en_US |
dc.subject | cellular immunity | en_US |
dc.subject | viral antigen delivery | en_US |
dc.subject | Medical Immunology | en_US |
dc.subject | Medical Immunology | en_US |
dc.title | The utilization of activated B cell for cell carrier for viral vectored antigen delivery in the acceleration of CD8 T cell recall response | en_US |
dc.type | thesis | en_US |
dc.contributor.department | Medical Sciences (Molecular Virology and Immunology Program) | en_US |
dc.description.degree | Master of Science (MSc) | en_US |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Size | Format | |
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fulltext.pdf | 1.34 MB | Adobe PDF | View/Open |
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