Please use this identifier to cite or link to this item:
http://hdl.handle.net/11375/11215| Title: | DNA Base Complexes of Platinum and the Antitumor Action of cis-Pt(NH₃)₂Cl₂ |
| Authors: | Sporanzini, Robert A. |
| Advisor: | Lock, C.J.L. |
| Department: | Chemistry |
| Keywords: | Chemistry;Chemistry |
| Publication Date: | Jun-1980 |
| Abstract: | <p>A previously unknown mode of binding of platinum complexes to the DNA bases is described. The binding mode is characteristic of cis and not trans-Pt(NH₃)₂Cl₂ and is thought to be related to the ability of cis compounds to form hydroxobridged dimers. It is suggested that the differing anticancer activity of cis and trans-Pt(NH₃)₂Cl₂ may result from this difference in chemistry which is based on the differing stereochemical requirements of cis and trans isomers.</p> |
| URI: | http://hdl.handle.net/11375/11215 |
| Identifier: | opendissertations/620 1979 1098275 |
| Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
| File | Size | Format | |
|---|---|---|---|
| fulltext.pdf | 7.53 MB | Adobe PDF | View/Open |
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