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http://hdl.handle.net/11375/11167
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DC Field | Value | Language |
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dc.contributor.advisor | Smieja, Marek Jozef | en_US |
dc.contributor.advisor | Thabane, Lehana | en_US |
dc.contributor.advisor | Andrew McIvor, Fiona Smaill | en_US |
dc.contributor.author | Cui, Qu | en_US |
dc.date.accessioned | 2014-06-18T16:53:46Z | - |
dc.date.available | 2014-06-18T16:53:46Z | - |
dc.date.created | 2011-09-12 | en_US |
dc.date.issued | 2011-10 | en_US |
dc.identifier.other | opendissertations/6156 | en_US |
dc.identifier.other | 7161 | en_US |
dc.identifier.other | 2231208 | en_US |
dc.identifier.uri | http://hdl.handle.net/11375/11167 | - |
dc.description.abstract | <p>Cigarette smoking is prevalent in HIV-infected people, resulting in higher mortality rate and more premature heart and lung diseases in the highly active antiretroviral therapy era. Smoking is a modifiable risk factor for these adverse outcomes and smoking cessation in HIV-positive smokers is feasible, although further efforts are needed to improve smoking cessation programs in HIV-positive persons.</p> <p>In this thesis, I examined the role of smoking in mortality and morbidity in HIV-positive Ontarians, and piloted a smoking cessation program featuring a novel smoking cessation aid, varenicline, in HIV-infected smokers. In addition, I explored three different methods to resolve missing data, by excluding, grouping and multiply imputing missing data. I adopted three different study designs in my thesis studies: retrospective cohort, cross-sectional and open label study.</p> <p>We found smoking prevalence in HIV-infected people was consistently higher than in the general population. Smoking was associated with a higher risk of death, of respiratory symptoms, hospitalization and chronic obstructive pulmonary disease, and with reduced lung function and less CD4-T-lymphocyte improvement over time. We found varenicline was as effective in HIV-positive smokers as in non-HIV smokers reported by previous studies.</p> | en_US |
dc.subject | HIV | en_US |
dc.subject | smoking | en_US |
dc.subject | smoking cessation | en_US |
dc.subject | multiple imputation | en_US |
dc.subject | varenicline | en_US |
dc.subject | Canada | en_US |
dc.subject | Clinical Epidemiology | en_US |
dc.subject | Clinical Epidemiology | en_US |
dc.title | EFFECT OF SMOKING AND CESSATION IN HIV-INFECTED PEOPLE | en_US |
dc.type | thesis | en_US |
dc.contributor.department | Health Research Methodology | en_US |
dc.description.degree | Doctor of Philosophy (PhD) | en_US |
Appears in Collections: | Open Access Dissertations and Theses |
Files in This Item:
File | Size | Format | |
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fulltext.pdf | 706.83 kB | Adobe PDF | View/Open |
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