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Please use this identifier to cite or link to this item: http://hdl.handle.net/11375/10974
Title: Characterizing the Role of Bmi1 in Human Brain Tumour Initiating Cells
Authors: O`Farrell, Erin L.
Advisor: Singh, Sheila
Department: Neuroscience
Keywords: Bmi1;Cancer;Glioblastoma;Brain Tumour Initiating Cell;Medicine and Health Sciences;Medicine and Health Sciences
Publication Date: Oct-2011
Abstract: <p>Bmi1 is a member of the Polycomb Group proteins and has been demonstrated as being vital in stem cell regulation. Bmi1 is overexpressed in many cancers, including glioblastoma, and has been shown to regulate cancer cell self-renewal and proliferation both <em>in vitro</em> and <em>in vivo</em>. This study aimed to determine if Bmi1 modulates brain tumour initiating cell properties using a spontaneous primary glioblastoma cell line and a commercial glioblastoma cell line. To determine the role of Bmi1 in glioblastoma cells, stem cell assays and <em>in vivo</em> analysis of tumour formation was performed on both control cells and Bmi1 knockdown cells. In both cell lines, Bmi1 was found to play a positive regulatory role in stem cell properties. When Bmi1 was knocked down in brain tumour initiating cells, properties such as self-renewal, proliferation and tumour formation were impaired compared to control cells. This study supports recent literature which shows that Bmi1 regulates stem cell properties in glioblastoma cells and supports the potential use of Bmi1 as a therapeutic target in glioblastoma brain tumours.<strong><br /> </strong></p>
URI: http://hdl.handle.net/11375/10974
Identifier: opendissertations/5980
6983
2180760
Appears in Collections:Open Access Dissertations and Theses

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