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About MacSphere

MacSphere is McMaster University's Institutional Repository. MacSphere brings together the institution's scholarly works under one umbrella to preserve and provide ongoing open access to them. MacSphere works have been selected and deposited by members of the McMaster community as part of our collective committment to sharing our knowledge with the world.

MacSphere is supported and hosted by the McMaster University Libraries.

To contribute, sign on to MacSphere with your McMaster Account. If you have any questions, refer to the user guide or contact the MacSphere Support Team for assistance.

Students wishing to deposit their PhD or Masters thesis, please follow the instructions outlined by the School of Graduate Studies.

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Communities in MacSphere

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Recent Submissions

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    Digital Research Commons Pilot - Strategic Plan Summary
    (2024-11) Brodeur, Jay; Di Nello, Angela; Scott, Rigel
    The Digital Research Commons Pilot (DRCP) was a three-year project to build a more connected, capable, and researcher-focused digital research infrastructure (DRI) ecosystem at McMaster. Read about the DRCP's vision, mission, goals and objectives.
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    GENERATING AN ADAPTER BASED UNIVERSAL T CELL THERAPY FOR CANCER
    (2026) Serniuck, Nickolas J; Rullo, Anthony; Bramson, Jonathan; Chemical Biology
    T cells present a powerful tool for cancer treatment given their ability to circulate throughout the body and “seek out and destroy” tumor deposits. The infusion of cancer patients with tumor-specific T cells is now a clinically proven treatment for cancer with six currently available. Accessibility to this promising therapeutic is limited by the requirement for the per-patient and per-target manufacturing of therapeutic T cells. Conventional synthetic antigen receptors (SARs) are rigid and typically limited to one tumor target. Given the vast number of potential targets this introduces significant timing, logistic and cost challenges when applying this approach broadly. Our program seeks to overcome these challenges by creating an on demand “off-the-shelf” solution. We propose the use of Universal SARs that can be programmed with target specificity after the engineered T cells are manufactured. A universal SAR employs an acceptor moiety which binds a molecular adapter that links the T cell to the tumor. By creating a library of adapters, a T cell engineered with a single universal SAR can be directed against multiple tumor targets. We have developed molecular adapters, termed covalent immune recruiters (CIRs), that chemically link immune receptors to cancer cells. Our grand vision is an offthe- shelf engineered T cell that is purpose-built for on demand CIR-mediated targeting and a library of CIRs directed against an array of tumor targets to yield a dynamic and affordable personalized therapy.
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    RISE brief 12: Rapid learning and improvement
    (2019-08) Gauvin, François-Pierre; Lavis, JN
    Key insights to support Ontario Health Teams in their work related to rapid learning and improvement.
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    RISE brief 11: Accountable-care organizations
    (2019-08) Moat, KA; Waddell, K; Lavis, JN
    Key insights to support Ontario Health Teams in their work related to accountable-care organizations.
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    RISE brief 10: Ontario’s health system
    (2019-07) Moat, KA; Lavis, JN
    Key insights to support Ontario Health Teams in their work related to Ontario’s health system.